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KMID : 0363320050260010221
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Journal of Korean Oriental Internal Medicine
2005 Volume.26 No. 1 p.221 ~ p.228
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Effects of HaengSoTang(HST), Gami-PalMiHwan(GPMH) on mucin secretion from airway goblet cells
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Lim Do-Hee
Lee Joung-Eun
Han Young-Joo
Hwang Ji-Ho
Cho Cheol-Jun
Bae Han-Ho
Park Yang-Chun
Chae Eun-Young
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Abstract
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The intent of this study is to investigate whether two oriental medical prescriptions named haengsotang(HST) and gami-palmihwan(GPMH) significantly effect mucin release from cultured hamster tracheal surface epithelial(HTSE) cells, Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of HST or GPMH to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of HST and GPMH on contractility of isolated tracheal smooth muscle were investigated. The results are consistant with the following assertions: (1) HST significantly inhibited mucin release from cultured HTSE cells, without cytotoxicity; (2) GPMH did not effect mucin release without cytotoxicity; (3) HST and GPMH did not effect contractility of isolated tracheal smooth muscle. These results suggest a need for further investigation of HST and its components, for its potential in oriental medicine prescriptions and novel agents that effectively regulate (inhibit) mucin secretion from airway goblet cells.
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KEYWORD
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airway goblet cell, mucin, haengsotang(HST), gami-palmihwan(GPMH)
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